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KMID : 0882420160900030243
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Korean Journal of Medicine
2016 Volume.90 No. 3 p.243 ~ p.247
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Acute Lymphoblastic Leukemia Diagnosed in a Patient with Acrome
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오영승:Oh Young-Seung
최민석:Choi Min-Seok/신진경:Shin Jin-Kyeong/권희석:Kwon Hee-Sun/손장원:Son Jang-Won/김성래:Kim Sung-Rae/유순집:Yoo Soon-Jib
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Abstract
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Acromegaly is a rare disorder caused by excessive amounts of growth hormone. The incidence of colorectal, breast, and thyroid carcinomas is increased in acromegaly. However, there have been few reports on hematological malignancies in acromegaly. We describe a patient who developed acute lymphoblastic leukemia during the course of acromegaly. A 35-year-old woman presented in February 2012 with unexplained lactation and amenorrhea for 4 months. Her growth hormone level was 12.6 μg/L, insulin-like growth factor 1 592.26 ng/mL, and prolactin 242 μg/L. A pituitary macroadenoma secreting GH and prolactin causing acromegaly was diagnosed. Considering her fertility, the dopamine agonist cabergoline 0.5 mg was administered in March 2012. In February 2014, she presented with cytopenia (hemoglobin 12.2 g/dL, white cell count 2.69 × 109/L, platelets 39 × 109/L) and hepatosplenomegaly. A bone marrow examination showed acute B cell lymphoblastic leukemia. She underwent chemotherapy and bone marrow transplantation. A follow-up bone marrow biopsy showed remission.
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KEYWORD
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Acromegaly, Precursor cell lymphoblastic leukemia-lymphoma, Insulin-like growth factor I
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